Traceless Staudinger Ligation for Biotinylation of
Current designs for small molecule theranostics, which serve both a diagnostic and therapeutic role, often involve dyes linked to therapeutic agents through a cleavable, traceless linker. In order to facilitate the separation of the dye from the therapeutic in response to a biological or chemical stimulus, linkers must incorporate elements of molecular logic, increasing their complexity and Amanda Ramdular - Graduate Researcher - New York To this end, we employed a pro-drug approach to conjugate the THF-AGE, 4-deoxyannomontacin (DAN) to a tumor specific vector, a 3-O-carbamoyl-mannose, via a traceless linker. Intramolecular thiolysis of 4-mercaptobutyrate esters Page 19 Issue in Honor of Prof. O. S. Tee ARKIVOC 2001 (xii) 19-26 Intramolecular thiolysis of 4-mercaptobutyrate esters: developing a “traceless” linker for alcohol release from self-assembled monolayers on gold Max B. Buchmann, Thomas M. Fyles,* Trevor Mischki, Todd Sutherland, Christine C. Tong, and Vivian L.Y. Yip Chemistry Department, University of Victoria, P.O. Box 3065, Victoria, B
Traceless cross-linker for photocleavable bioconjugation
The most popular linker is the protease cleavable linker that contains a valine-citrulline-para-aminobenzyl-carbamate moiety (vc-PABC). 10 This is a traceless linker that allows the release of amine containing cytotoxins. Many di-, tri-, and tetra-peptide sequences are cleaved by proteases and changing the sequence can facilitate the synthesis Intramolecular thiolysis of 4-mercaptobutyrate esters In order for the “traceless” linker to be effective, a process for reductively cleaving the gold-sulfur bond and simultaneously releasing the alcohol is required. As suggested in Figure 1, thiolactone was evaluated for its potential to release the alcohol after reductive cleavage of the gold-sulfur bond. Traceless Living/Zero Waste
NJ BIO — Introduction to Antibody-Drug Conjugates
Traceless Linkers - Combinatorial Chemistry Mar 10, 2020